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Oncology Precision Medicine : A Concept of Identifying Specific Genes

 The human genome comprises DNA sequences that provide a code for the synthesis and regulation of an estimated 20,000 proteins. However, there is a natural variation between individuals’ genomes that leads to differences in structure, function, and production of proteins. Precision medicine is a concept of identifying such variations in specific genes that affect the health response to interventions. Contrary to the empiric medicine method, the precision medicine approach begins with testing and analysis of the patient to pre-determine the best fit mode of treatment for the patient. Following the accomplishment of the human genome project, there had been significant progress in characterizing the human epigenome, proteome, metabolome, and pharmacogenomics that has led to the evolution of customized healthcare for the individual, especially patients suffering from cancer. 

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Furthermore, germline mutations and somatic mutations are critical in driving cancer imitation or progression and thus the study of structural variations via sequencing or other molecular diagnostic techniques, which have been an integral part of precision medicine and may help in the early-stage screening of the disease. Moreover, precise screening also allows targeted therapy, which has a significant role in cancer treatment as through this mode, cancer cell growth can be blocked via interfering with the targeted molecules that are involved in cancer. Further, with the global expansion of cancer incidences at such a rapid rate, there has been a demand for alternative medicine other than the traditional one. Hence, the aforementioned factors have posed a necessity for an effective treatment method that involves the precision medicine approach.


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